程亮教授课题组在acs nano上发表论文-k8凯发赢家一触即发

作者：

jie wu^1,2,3, zhicheng liu³, li wang³, zifan pei³, zhihui han³, xiaoliang cui³, xiaoxiao pan³, jie cao³, yechen huang³, shumin sun³, jianman wang¹, chong cheng⁴, and liang cheng^1,2,3*

单位：

¹school of pharmacy, faculty of medicine, macau university of science and technology, taipa, macau sar 999078, china

²macao institute of materials science and engineering, macau university of science and technology, taipa, macau sar 999078, china

³institute of functional nano & soft materials (funsom), jiangsu key laboratory for carbon-based functional materials & devices, soochow university, suzhou 215123, china.

⁴college of polymer science and engineering, state key laboratory of polymer materials engineering, sichuan university, chengdu 610065, china.

摘要：

increasing evidence illustrates the significance of promoting tumor immunogenicity and an efficient immune response in immunotherapy, but the immunosuppressive tumor microenvironment (tme) remains an obstacle. herein, alzn hydrotalcite (azoh) was synthesized as a pyroptosis inducer and further loaded with r848 to formulate r@azoh. r@azoh efficiently triggered ct26 cell pyroptosis through zn² overload-evoked mitochondrial dysfunction and its downstream caspase-1/gsdmd pathway, resulting in the release of inflammatory cytokines, membrane fracture, and immunogenic cell death (icd). moreover, r@azoh served as antigen traps to facilitate antigen presentation, thereby cooperating with tlr activation to dually stimulate dendritic cells (dcs). the combination of r@azoh rapidly initiated innate immunity and prolonged the adaptive immune response, resulting in the suppression of tumor growth, immune cell activation and a “hot” tumor niche. the potent antitumor immunity was further enhanced by combination with an immune checkpoint inhibitor (αctla-4), which inhibited both primary and distant tumors, as well as systemic immune activation. astonishingly, we also explored the potential application of r@azoh as a tumor vaccine adjuvant and demonstrated its ability to elicit immunological memory to prevent tumor growth in an orthotopic melanoma model. overall, our work emphasized the potential application of combining pyroptosis and tlr activation to stimulate both innate and adaptive immunity to overcome the immunosuppressivetme and presented a good adjuvant candidate.

影响因子：

15.8

分区情况：

一区

链接：

责任编辑：杜欣