冯良珠教授与刘庄教授合作在adv. mater.上发表论文-k8凯发赢家一触即发

作者：

shuai zhang, chunjie wang, yujie zhu, juxin gao, yifan yan, minming chen, xiaoying yan, zhuang liu*, and liangzhu feng*

单位：

institute of functional nano & soft materials (funsom), jiangsu key laboratory for carbon-based functional materials & devices, soochow university, 199 ren’ai road, suzhou, jiangsu 215123, p. r. china.

摘要：

the radiotherapy-induced release of dna fragments can stimulate the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cgas-sting) pathway to prime antitumor immunity, but this pathway is expected to be less potent because of the inefficient cytosolic delivery of negatively charged dna fragments. in this study, manganese-coordinated chitosan (cs-mn) microparticles with selective dna-capturing capacity are concisely prepared via a coordination-directed one-pot synthesis process to potentiate the immunogenicity of radiotherapy. the obtained cs-mn microparticles that undergo rapid disassembly under physiological conditions can selectively bind with dna to form positively charged dna-cs assemblies because of the strong electrostatic interaction between linear chitosan and dna molecules. they thus enable efficient cytosolic delivery of dna in the presence of serum to cooperate with mn² to activate the cgas-sting pathway in dendritic cells. upon intratumoral injection, the cs-mn microparticles markedly enhance the efficacy of radiotherapy against both irradiated and distal tumors in different tumor models via collectively promoting tumor-infiltrating cd8 t-cell stemness and the activation of innate immunity. the radiosensitization effect of cs-mn microparticles can be further augmented by concurrently applying anti-programmed cell death protein 1 (anti-pd-1) immunotherapy. this work highlights an ingenious strategy to prepare trojan horse-like dna-capturing microparticles as cgas-sting-activating radiosensitizers for effective radioimmunotherapy

影响因子：

27.4

分区情况：

一区

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